Transformative Research Priorities for the Epilepsies

Broaden understanding of epileptogenesis

Why would this research priority transform epilepsy research, our understanding of the epilepsies, and/or treatment of the epilepsies? :

The American Epilepsy Society considers this a high priority. As in human cancer, there will likely be common and overarching processes or mechanisms that lead to the establishment of the epileptic network. By analogy, all cancers stem from abnormally exuberant cell proliferation, and epilepsy reflects abnormal synchrony of neural networks. But the processes and mechanisms leading to seizures in SCN1A may be very different than CDKL5 and likely, from TBI- or tumor-associated seizures. From a treatment perspective, we have moved from big mechanisms drugs i.e., phenytoin, to targeted therapies i.e., everolimus, fenfluramine. Consider editing the priority to emphasize that understanding of epileptogenesis should include pan and etiology-dependent mechanisms.

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Idea No. 124