2020 Epilepsy Research Benchmarks

Human Brain Organoid Models

Brain organoids, a new class of brain surrogate, have gained traction as a model for studying the intricacies of the human brain by using advancements in stem cell biology to recapitulate aspects of the developing human brain in vitro. Brain organoids generated from human pluripotent stem cells (hPSCs) offer a means to study human disease. Recent observation of nested EEG-like signals spontaneously emerge from these organoids suggests that this model could be used to study epilepsy. Different from animal models and postmortem tissues, brain organoids can be used to dissect molecular, cellular, and network mechanisms in a live human context outside the uterus. This is a complementary and important tool to understand how epilepsy develops in humans. Moreover, since these brain organoids can be derived from live individuals, it can be used for personalizing research and treatment.

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Idea No. 43

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