Transformative Research Priorities for the Epilepsies

Macroscopic network mechanisms of focal epilepsy

Why would this research priority transform epilepsy research, our understanding of the epilepsies, and/or treatment of the epilepsies? :

Much of the field of epilepsy still harbors long-held ideas about what creates the patterns of neural electrophysiology that results in focal seizures, a lot of which has not been experimentally established. Much of this activity may have the spatiotemporal characteristics that would be unlikely to be captured with standard imaging protocols. Better understanding of these mechanisms will not only better reveal the underlying dynamics of seizure generation and progression but may lead to the kind of improved understanding that would impact treatment options. This would be especially true for drug-resistant seizures.

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Idea No. 148