Few benchmarks will have large clinical impact if accomplished alone. Most benchmarks, specifically those relating to integrating large data sets and developing models, depend upon integrating knowledge gained from progress toward other benchmarks. In Area II, for example, benchmarks A, B, and C could be addressed separately, by a variety of innovative research approaches large and small. However, benchmark F needs input from A, B, and C as substrate. Similarly, data from A, B, C, and F can be used to develop models, targets, and treatments as in benchmarks D and E. (see example of Area II in the attachment.) NINDS should consider RFAs for both grants and cooperative agreements carefully to impart a strategy to pursuit of the benchmarks.
Idea No. 47