Showing 5 ideas for tag "cure"
(@jayetta) kudos icon 10

Transformative Research Priorities for the Epilepsies

Laying the Foundation for an Epilepsy Moonshot trending idea

More substantive research priorities, however well framed and targeted, can not alone overcome the inefficiencies and silo-ed structure for clinical care and research in the epilepsies.

By integrating clinical care and research—the standard for decades in pediatric oncology—we will get on a path where we will start seeing improvements in the quality of life for all those living with and too often dying from epilepsy.... more »

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(@dboison) kudos icon 1

Transformative Research Priorities for the Epilepsies

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Metabolic and biochemical pathways are an understudied research area in the epilepsies. Biochemical pathways provide crucial links between gene expression (e.g. via epigenetic modification), energy metabolism (mitochondria, ATP), neuron-glia interactions, and finally neuronal excitability. Derailment of metabolic functions can affect a complex system such as the brain on multiple different levels and metabolism or biochemistry... more »

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(@muotri) kudos icon 1

2020 Epilepsy Research Benchmarks

Human Brain Organoid Models

Brain organoids, a new class of brain surrogate, have gained traction as a model for studying the intricacies of the human brain by using advancements in stem cell biology to recapitulate aspects of the developing human brain in vitro. Brain organoids generated from human pluripotent stem cells (hPSCs) offer a means to study human disease. Recent observation of nested EEG-like signals spontaneously emerge from these organoids... more »

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(@jayetta) kudos icon 3

2020 Epilepsy Research Benchmarks

We need clinical trials with an N of EVERYONE trending idea

Coming from the world of families with children ravaged by the many rare and catastrophic epilepsies, we suggest consideration of a benchmark where every child with epilepsy is enrolled in a clinical trial. Our children are already guinea pigs, but their experiences are not treated with the respect of a common lab rat. The vital data on the impact of the constantly changing cocktails to try to control their treatment... more »

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