Understanding the etiology of late-onset epilepsy
One third of late-onset epilepsy have no known etiology. Cognitive symptoms are common with LOE and a third of these patients have mild cognitive impairment. Some patients with LOE have transient epileptic amnesia (TEA), while others develop neurodegenerative diseases such as Alzheimer's disease or dementia with Lewy bodies. Autoimmune causes have variable clinical presentations.
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Improve treatment options for controlling seizures and epilepsy
Incorporate findings from the NINDS workshop entitled, "Metabolism-based Therapies for Epilepsy" (Nov 9. 2020)
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Cure epilepsy
The current benchmarks never say the words "cure epilepsy". It is vaguely suggested by Area II, component E, but why be vague? We want to CURE EPILEPSY. Lets say that loud and clear, right?
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We need clinical trials with an N of EVERYONE

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Focus on Networks

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The integration of human values and ethics into all DRE research
Incorporate ethics approaches and use human values to guide innovation in research and technology for drug resistant epilepsy (DRE).
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A cure is important but so is the person
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Human Brain Organoid Models

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Strategically integrating the benchmarks for clarity

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Other
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Modifier genetics to identify drug targets and mechanisms
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Research in Health Disparities
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Epilepsy-related "training" datasets for machine learning
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Laying the Foundation for an Epilepsy Moonshot

By integrating clinical care and research—the standard for decades in pediatric oncology—we will get on a path where we will start seeing improvements in the quality of life for all those living with and too often dying from epilepsy.... more »