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The endocannabinoid system serves a critical role in homeostatic regulation through its influence on processes underlying appetite, pain, reward, and stress, and cannabis has long been used for the related modulatory effects it provides through tetrahydrocannabinol (THC).

We investigated how THC exposure relates to tissue microstructure of the cerebral cortex and subcortical nuclei using computational modeling of diffusion... more »

This video shows the evolutionary change in hippocampus and brain structure shown from human back to mouse.

Lattice light sheet microscopy reveals presynaptic collateral dynamics in the developing calyx of Held during the first week of life in the auditory brainstem of the mouse.

Tractography of three critical amygdala pathways: the ventral amygdalofugal pathway, the stria terminalis and the amygdala-prefrontal pathway.

This visualization depicts lenticulostriate arteries (LSAs), which are very small blood vessels in the brain. The data was collected by a ultra-high field 7Tesla MRI scanner. Visualizing these vessels using non-invasive MRI scans can help advance the study and treatment of cerebral small vessel disease.

In this study, we introduced a novel zoomed 3D pseudo-continuous ASL (pCASL) technique at 7T with high spatial resolution (1-mm isotropic) and sensitivity to characterize layer-dependent resting and task activation induced perfusion activity in the human motor cortex. For the first time, multi-delay pCASL was applied to measure variations of arterial transit time (ATT) and resting state CBF across cortical layers, illustrating... more »

A Kuhl cell is a synthetic, excitable cell that can be activated by brief pulses of blue light and serves as a platform for screening the next generation of bio-sensors. In this live cell system, blue light activates an adenylyl cyclase enzyme (bPAC) that increases intracellular cAMP. In Kuhl cells bPAC creates a pseudo action potential in HEK293 cells with Kir2.1, NavD, and CNG channels. The behavior of HCN2 was visually... more »

Pyramidal tract of an HCP subject reconstructed in vivo using Radial DSI and ODF-Fingerprinting. Improved reconstruction of fibers crossing at shallow angles ensured by ODF-Fingerprinting allowed to reproduce the reach fanning shape of cortical terminations of the tract. Images were rendered in DSI Studio.

3D rendered image of segmented Perivascular Spaces (PVSs), superimposed on a high-resolution 7 Tesla anatomical MRI of a healthy adult brain. PVSs, also known as Virchow-Robin spaces, are fluid-filled structures that accompany vessels entering (penetrating arteries) or leaving (draining veins) the cerebral cortex. Mapping PVSs has significant clinical value because it plays a key role in the circulation of the cerebrospinal... more »

360 degree view of deep brain stimulation (DBS) lead placement in one participant that underwent DBS surgery for obsessive compulsive disorder (OCD).

Serially sectioned spinal cord with marked coordinates of V1-Interneurons and cells infected by neuronal tracer pseudorabies virus - 3D reconstructed.

In a woman presenting with small centrum semiovale hemorrhage, arterial DSA with rotational angiography revealed no evidence of aneurysm or AVM. Rather, it showed a large developmental venous anomaly and, for better visualization, a venous 3D DSA was also obtained. The 2 subtracted volumes were then fused to show concomitant representation of the arteries and veins. Developmental venous anomaly is an embryologically arrested... more »