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Mouse brain showing green AAV-transduced cells in the cortex and hippocampus. Neurons are labeled red and nuclei are blue.

This rendering of a model of mouse primary visual cortex with a Neuropixels probe was created using a new tool, VND (Visual Neuronal Dynamics).

Hippocampal CA1 pyramidal neuron in the mouse, recorded from the distal dendrite using patch clamp electrophysiology. The recorded location is visible as the gap in the dendrite. The neuron was filled with biocytin during recording and immunostained with streptavidin-647 post hoc. Confocal image was filtered using ImageJ.

360 degree view of deep brain stimulation (DBS) lead placement in one participant that underwent DBS surgery for obsessive compulsive disorder (OCD).

Tractography of three critical amygdala pathways: the ventral amygdalofugal pathway, the stria terminalis and the amygdala-prefrontal pathway.

The endocannabinoid system serves a critical role in homeostatic regulation through its influence on processes underlying appetite, pain, reward, and stress, and cannabis has long been used for the related modulatory effects it provides through tetrahydrocannabinol (THC).

We investigated how THC exposure relates to tissue microstructure of the cerebral cortex and subcortical nuclei using computational modeling of diffusion... more »

Pyramidal tract of an HCP subject reconstructed in vivo using Radial DSI and ODF-Fingerprinting. Improved reconstruction of fibers crossing at shallow angles ensured by ODF-Fingerprinting allowed to reproduce the reach fanning shape of cortical terminations of the tract. Images were rendered in DSI Studio.

Serially sectioned spinal cord with marked coordinates of V1-Interneurons and cells infected by neuronal tracer pseudorabies virus - 3D reconstructed.

3D rendered image of segmented Perivascular Spaces (PVSs), superimposed on a high-resolution 7 Tesla anatomical MRI of a healthy adult brain. PVSs, also known as Virchow-Robin spaces, are fluid-filled structures that accompany vessels entering (penetrating arteries) or leaving (draining veins) the cerebral cortex. Mapping PVSs has significant clinical value because it plays a key role in the circulation of the cerebrospinal... more »

Lattice light sheet microscopy reveals presynaptic collateral dynamics in the developing calyx of Held during the first week of life in the auditory brainstem of the mouse.

This video shows the evolutionary change in hippocampus and brain structure shown from human back to mouse.

In this study, we introduced a novel zoomed 3D pseudo-continuous ASL (pCASL) technique at 7T with high spatial resolution (1-mm isotropic) and sensitivity to characterize layer-dependent resting and task activation induced perfusion activity in the human motor cortex. For the first time, multi-delay pCASL was applied to measure variations of arterial transit time (ATT) and resting state CBF across cortical layers, illustrating... more »

MRI Pop Art

This is Sindhi Ajrak print digitally painted on the Corticospinal Tract (CST) Left. Ajrak print is 3000 years old unique form of block-printing found in Sindh, Pakistan. Ajrak print is mostly hand-painted on shawls made using block printing by stamps. Ajrak has become a symbol of the Sindhi culture and traditions. Using my programming skills, I painted Ajrak on my favorite white matter tract, CST.

3D super-resolution image of immunofluorescence-labeled ChR2–EYFP on dendrites in 50-μm-thick brain section of visual cortical circuits.