This idea would assist the basic research community in transforming preclinical findings to clinical application.
If more research was done, specifically on the link between epilepsy and late stage pregnancy, more OB/GYNs could be educated on the need to induce earlier to prevent epilespy.
By integrating clinical care and research—the standard for decades in pediatric oncology—we will get on a path where we will start seeing improvements in the quality of life for all those living with and too often dying from epilepsy.... more »
For example, a patient with as yet unexplained non-acquired epilepsy should be considered to have genetic epilepsy until proven otherwise and appropriately evaluated. If the first line of evaluation is unrevealing he or she should have an iterative re-analysis of cause in tandem with empiric therapy.... more »
The lowest hanging fruit for epilepsy models is to use CRISPR-knock-in (KI) strategies to create mice expressing human gene variants rather than simply presuming gene knockout or over-expression will accurately model a loss- or gain-of-function mutation.... more »
This should be a clear mandate for future and collaborative investigation in epilepsy, as it provides an opportunity to bring in scientists from disciplines outside of the epilepsy field.
This focus should be on epilepsy alone, as the co-morbidities add a level of complexity that may make progress slow.
With genetic and epigenetic mechanisms represented strongly in other... more »