If more research was done, specifically on the link between epilepsy and late stage pregnancy, more OB/GYNs could be educated on the need to induce earlier to prevent epilespy.
• Grand Challenge idea: "Biomarkers for Prevention before Seizure Onset" – Following the example of TSC and vigabatrin, a grand challenge may be to identify the range of other epilepsies that can be accurately identified before seizures emerge, and develop targeted programs to develop biomarkers and preventive treatments. Examples could include individuals with higher... more »
One third of late-onset epilepsy have no known etiology. Cognitive symptoms are common with LOE and a third of these patients have mild cognitive impairment. Some patients with LOE have transient epileptic amnesia (TEA), while others develop neurodegenerative diseases such as Alzheimer's disease or dementia with Lewy bodies. Autoimmune causes have variable clinical presentations.
Incorporate findings from the NINDS workshop entitled, "Metabolism-based Therapies for Epilepsy" (Nov 9. 2020)
The current benchmarks never say the words "cure epilepsy". It is vaguely suggested by Area II, component E, but why be vague? We want to CURE EPILEPSY. Lets say that loud and clear, right?
Incorporate ethics approaches and use human values to guide innovation in research and technology for drug resistant epilepsy (DRE).
By integrating clinical care and research—the standard for decades in pediatric oncology—we will get on a path where we will start seeing improvements in the quality of life for all those living with and too often dying from epilepsy.... more »
For example, a patient with as yet unexplained non-acquired epilepsy should be considered to have genetic epilepsy until proven otherwise and appropriately evaluated. If the first line of evaluation is unrevealing he or she should have an iterative re-analysis of cause in tandem with empiric therapy.... more »