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Has evolution conserved microcircuitry that performs a small number of identifiable, verifiable canonical computations?

If so, connectomes can add value not by their completeness, but by their presentation of motifs which can be categorized as one of a number of basis functions. In spite of the ongoing, global, development of connectomes, we incompletely understand these general and reductionist questions:

Exactly what... more »

The cerebellum has often been overlooked but may be key to understanding depression, anxiety, and other psychological ailments and even consciousness. Mapping the circuitry of the cerebellum can provide insight on how to bring the cerebellum to full activity. This could reduce the need for current anti depressants such as MAOIs. We know that certain chemical substances such as N-Dimethyltryptamine and Psilocin cause neuronal... more »

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I just today learned of the Brain Connectivity workshop series. We have a paper on upscaling x-ray nanoimaging to macroscopic specimens. See Fig. 8a in particular.

Mouse brain showing green AAV-transduced cells in the cortex and hippocampus. Neurons are labeled red and nuclei are blue.

MRI Pop Art

This image was created with confocal microscopy, FIJI processing, Blender rendering, and Photoshop (to produce Biobot nanoship). Rat meningeal tissue was labeled with antibodies against proteins involved in chronic migraine headaches. Calcitonin gene-related peptide (CGRP, red), and CGRP receptor proteins, receptor activity modifying protein 1 (RAMP1, blue) and calcitonin-like receptor (CLR, green). Geometry of meningeal... more »

Hippocampal CA1 pyramidal neuron in the mouse, recorded from the distal dendrite using patch clamp electrophysiology. The recorded location is visible as the gap in the dendrite. The neuron was filled with biocytin during recording and immunostained with streptavidin-647 post hoc. Confocal image was filtered using ImageJ.

This is Sindhi Ajrak print digitally painted on the Corticospinal Tract (CST) Left. Ajrak print is 3000 years old unique form of block-printing found in Sindh, Pakistan. Ajrak print is mostly hand-painted on shawls made using block printing by stamps. Ajrak has become a symbol of the Sindhi culture and traditions. Using my programming skills, I painted Ajrak on my favorite white matter tract, CST.

3D reconstruction acquired using confocal microscopy. Dorsal habenular neurons express mCherry (magenta). Neurons producing Relaxin-3 neuropeptide express GFP (green).

Isolated cerebral microvessels from transgenic sickle mouse. Immunofluorescence staining with red (CD31, endothelial cell marker) and green (Aquaporin-4, astrocyte marker), counterstained with sparkling blue (DAPI, nuclei detector).